The clinical success of 3D-printed indirect dental ceramic restorations depends on cavity preparation, cementation system and in particular, surface pretreatment of the indirect restoration. The adhesive strength and bonding between resin composite cement and indirect restoration are vital factors. How do 3D-printed ceramics differ from CAD/CAM or slip cast ceramics and why? Micromechanical retention is also a very important consideration: but which one dominates: retention or chemical adhesion? Adhesion strength can be significantly increased by application of a mediator compound, a primer. A silane coupling agent, with a reactive silane monomer, is the key. Silane primers contain silane monomers with different reactive functional groups. They react and form a linkage to couple chemically different materials. In prosthetic dentistry, either etching with hydrofluoric acid, HF, or silica-coating of the indirect restoration is a mandatory pretreatment before silane application and cementation. It is noteworthy that all resin composite materials, packable or flowable, contain silanized fillers. After pretreating the surface with silica-coating the surface is more reactive for bond formation. Surface pretreatment of some indirect dental restorative materials is of great importance in dentistry. What are the current recommendations for cementations in the modern adhesive dentistry and bonding 3D-printed dental materials? Should we acid-etch or silica-coat and why?